Role of the 2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia
نویسندگان
چکیده
Elham Zarrinpashneh, Karla Carjaval, Christophe Beauloye, Audrey Ginion, Philippe Mateo, Anne-Catherine Pouleur, Sandrine Horman, Sophie Vaulont, Jacqueline Hoerter, Benoit Viollet, Louis Hue, Jean-Louis Vanoverschelde, and Luc Bertrand Division of Cardiology, School of Medicine, Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, Brussels, Belgium; and Institut National de la Santé et de la Recherche Médicale, Unité 769, Université Paris-Sud, and IFR-141, Châtenay-Malabry; and Unité 567 Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 8104 Centre National de la Recherche Scientifique, René Descartes University, Institut Cochin, Department of Endocrinology, Metabolism. and Cancer, Paris, France
منابع مشابه
Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia.
AMP-activated protein kinase (AMPK) is a major sensor and regulator of the energetic state of the cell. Little is known about the specific role of AMPKalpha(2), the major AMPK isoform in the heart, in response to global ischemia. We used AMPKalpha(2)-knockout (AMPKalpha(2)(-/-)) mice to evaluate the consequences of AMPKalpha(2) deletion during normoxia and ischemia, with glucose as the sole sub...
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